Minimising conformational bias in fluoroprolines through vicinal difluorination-Reference-Cited by-同舟云学术

Minimising conformational bias in fluoroprolines through vicinal difluorination

Published:2018 Issue:40 Volume:54 Page:5118-5121
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hofman Gert-Jan¹²³⁴⁵^ORCID,Ottoy Emile⁶⁷⁸⁹^ORCID,Light Mark E.¹²³⁴⁵^ORCID,Kieffer Bruno¹⁰¹¹¹²^ORCID,Kuprov Ilya¹²³⁴⁵^ORCID,Martins Jose C.⁶⁷⁸⁹^ORCID,Sinnaeve Davy⁶⁷⁸⁹^ORCID,Linclau Bruno¹²³⁴⁵^ORCID

Affiliation:

1. Chemistry

2. University of Southampton

3. Highfield

4. Southampton SO17 1BJ

5. UK

6. Department of Organic and Macromolecular Chemistry

7. Ghent University

8. Ghent B-9000

9. Belgium

10. IGBMC – CNRS UMR 7104 – Inserm U 1258

11. BP 10142, 67404 Illkirch

12. France

Abstract

Combining the 4S-fluoro and 3R-fluoromotifs, which each instill an opposing conformational bias, leads to a fluorinated proline with a similar conformational profile to proline.

Funder

Engineering and Physical Sciences Research Council

Fonds Wetenschappelijk Onderzoek

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC01493K

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3. Both the cis-trans equilibrium and isomerization dynamics of a single proline amide modulate 2-microglobulin amyloid assembly

4. Collagen Structure and Stability

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