Expedient access to saturated nitrogen heterocycles by photoredox cyclization of imino-tethered dihydropyridines
Author:
Affiliation:
1. Celgene Corporation
2. Cambridge
3. USA
Abstract
This work describes an expedient access to sp3-rich nitrogen heterocycles via mild photoredox cleavage of 4-alkyl-1,4-dihydropyridines followed by cyclization of the resultant carbon-centered radicals with tethered imines.
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2019/SC/C9SC03429C
Reference55 articles.
1. Natural product and natural product derived drugs in clinical trials
2. Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles
3. Synthesis of Natural-Product-Like Molecules with Over Eighty Distinct Scaffolds
4. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
5. The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
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