Limpid hydrogels from β-turn motif-connected tandem repeats of Aβ16

Limpid hydrogels from β-turn motif-connected tandem repeats of Aβ16–22

Published:2019 Issue:24 Volume:15 Page:4827-4835
ISSN:1744-683X
Container-title:Soft Matter
language:en
Short-container-title:Soft Matter

Author:

Datta Debika¹²³⁴^ORCID,Kumar Vishnu¹²³⁴^ORCID,Kumar Sachin¹²³⁴^ORCID,Nagaraj Ramakrishnan⁵⁶⁴^ORCID,Chaudhary Nitin¹²³⁴^ORCID

Affiliation:

1. Department of Biosciences and Bioengineering

2. Indian Institute of Technology Guwahati

3. Guwahati 781 039

4. India

5. CSIR-Centre for Cellular and Molecular Biology

6. Hyderabad 500 007

Abstract

Aβ_16–22(Ac-KLVFFAE-am) is non-hydrogelating up to a concentration of 20 mM; two Aβ_16–22 repeats connected via turn-inducing motifs, however, form hydrogels.

Funder

Department of Biotechnology, Ministry of Science and Technology

Ministry of Human Resource Development

Department of Science and Technology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/SM/C9SM00343F

Reference59 articles.

1. Diffusible, nonfibrillar ligands derived from A 1-42 are potent central nervous system neurotoxins

2. Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

3. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics

4. Functional amyloid – from bacteria to humans

5. Amyloid-based nanosensors and nanodevices

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Peptide-based nanomaterials: applications and challenges;De Novo Peptide Design;2023

2. Advances in hybrid peptide-based self-assembly systems and their applications;Biomaterials Science;2022

3. Electric field modulated peptide based hydrogel nanocatalysts;Soft Matter;2021

4. Peptide-based hydrogels for biomedical applications;Translational Biotechnology;2021

5. Trimers Conjugated to Fibrin Hydrogels Promote Salivary Gland Function;Journal of Dental Research;2020-10-10