Insights into self-degradation of cysteine esters and amides under physiological conditions yield new cleavable chemistry-Reference-Cited by-同舟云学术

Insights into self-degradation of cysteine esters and amides under physiological conditions yield new cleavable chemistry

Published:2023 Issue:28 Volume:59 Page:4233-4236
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Kang Xueying¹,Ye Haishun¹,Liu Shanshan¹,Tu Xiaoqiang¹,Zhu Jiqin¹,Sun Hongyan²^ORCID,Yi Long¹^ORCID

Affiliation:

1. State Key Laboratory of Organic–Inorganic Composites and Beijing Key Lab of Bioprocess, Beijing University of Chemical Technology (BUCT), Beijing 100029, China

2. Department of Chemistry and Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, 83 TatChee Avenue, Kowloon, Hong Kong, China

Abstract

Cysteine esters and amides spontaneously degrade under physiological conditions to generate H2S. This discovery not only provides new insights into fundamental science issues, but also inspires a class of tunable cleavage motifs for prodrug design.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC00684K

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3. Prebiotic Peptides: Molecular Hubs in the Origin of Life

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5. The Role of Hydrogen Sulfide in Evolution and the Evolution of Hydrogen Sulfide in Metabolism and Signaling

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