3-D individual cell based computational modeling of tumor cell–macrophage paracrine signaling mediated by EGF and CSF-1 gradients-Reference-Cited by-同舟云学术

3-D individual cell based computational modeling of tumor cell–macrophage paracrine signaling mediated by EGF and CSF-1 gradients

Published:2016 Issue:1 Volume:8 Page:104-119
ISSN:1757-9694
Container-title:Integrative Biology
language:en
Short-container-title:Integr. Biol.

Author:

Knutsdottir Hildur¹²³⁴⁵,Condeelis John S.⁶⁷⁸⁹,Palsson Eirikur⁵¹⁰¹¹⁴

Affiliation:

1. Mathematics Department/Institute of Applied Mathematics

2. University of British Columbia

3. Vancouver

4. Canada

5. Department of Biology

6. Department of Anatomy and Structural Biology

7. Albert Einstein College of Medicine

8. Bronx

9. USA

10. Simon Fraser University

11. Burnaby

Abstract

Our 3-D computational model shows that EGF-CSF1 paracrine signaling between tumor cells and macrophages enhances cell invasiveness and leads to co-migration in a specific cell ratio.

Funder

Natural Sciences and Engineering Research Council of Canada

Publisher

Oxford University Press (OUP)

Subject

Biochemistry,Biophysics

Link

http://pubs.rsc.org/en/content/articlepdf/2016/IB/C5IB00201J

Reference32 articles.

1. A Paracrine Loop between Tumor Cells and Macrophages Is Required for Tumor Cell Migration in Mammary Tumors

2. Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

3. Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

4. Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

5. Distinct Role of Macrophages in Different Tumor Microenvironments

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