Biophysical evaluation to categorize pathogenicity of cancer-predisposing mutations identified in the BARD1 BRCT domain-Reference-Cited by-同舟云学术

Biophysical evaluation to categorize pathogenicity of cancer-predisposing mutations identified in the BARD1 BRCT domain

Published:2018 Issue:59 Volume:8 Page:34056-34068
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Choudhary Rajan Kumar¹²³⁴⁵,Siddiqui M. Quadir¹²³⁶⁷,Gadewal Nikhil¹²³,Kumar Nachimuthu Senthil⁸⁹¹⁰³,Kuligina Ekaterina S.¹¹¹²¹³¹⁴¹⁵,Varma Ashok K.¹²³¹⁶¹⁷^ORCID

Affiliation:

1. Advanced Centre for Treatment, Research and Education in Cancer

2. Navi Mumbai

3. India

4. Department of Biological Chemistry

5. The Alexander Silberman Institute of Life Sciences

6. University of Nebraska Medical Centre

7. Omaha

8. Department of Biotechnology

9. Mizoram University (A Central University)

10. Aizawl – 796 004

11. Laboratory of Molecular Oncology

12. Department of Tumor Growth Biology

13. N.N. Petrov Institute of Oncology

14. St.-Petersburg

15. Russia

16. Homi Bhabha National Institute

17. Training School Complex

Abstract

The BRCT domain of BARD1 (BARD1 BRCT) is involved in many cellular processes such as DNA damage repair (DDR) and cell-cycle checkpoint regulation.

Funder

Department of Science and Technology, Ministry of Science and Technology

Russian Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA06524A

Reference61 articles.

1. The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

2. BRCA1 RING Domain Cancer-predisposing Mutations

3. The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

4. The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation

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