A novel 2-cyanobenzothiazole-based 18F prosthetic group for conjugation to 1,2-aminothiol-bearing targeting vectors-Reference-Cited by-同舟云学术

A novel 2-cyanobenzothiazole-based 18F prosthetic group for conjugation to 1,2-aminothiol-bearing targeting vectors

Published:2015 Issue:12 Volume:13 Page:3667-3676
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Inkster James A. H.¹²³⁴,Colin Didier J.⁵⁶³⁴,Seimbille Yann¹²³⁴

Affiliation:

1. University Hospitals of Geneva

2. Cyclotron Unit

3. Geneva

4. Switzerland

5. University of Geneva

6. Centre for BioMedical Imaging

Abstract

[¹⁸F]FPyPEGCBT is a new ¹⁸F labelling agent which contains a 2-substituted pyridine for incorporation of [¹⁸F]F⁻ and a 2-cyanobenzothiazole moiety for chemo-selective conjugation to 1,2-aminothiol-bearing biomolecules.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02637C

Reference35 articles.

1. 2-[18F]fluoropyridines by no-carrier-added nucleophilic aromatic substitution with [18F]FK-K222—a comparative study

2. 2-, 3- and 4-[18F]Fluoropyridine by no-carrier-added nucleophilic aromatic substitution with K[18F]F-K222- a comparative study

3. 1-[3-(2-[18F]Fluoropyridin-3-yloxy)propyl]pyrrole-2,5-dione: Design, Synthesis, and Radiosynthesis of a New [18F]Fluoropyridine-Based Maleimide Reagent for the Labeling of Peptides and Proteins

4. Design and Synthesis of a New [18F]Fluoropyridine-Based Haloacetamide Reagent for the Labeling of Oligonucleotides: 2-Bromo-N-[3-(2-[18F]fluoropyridin-3-yloxy)propyl]acetamide

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