Benzocyclohexane oxide derivatives and neolignans from Piper betle inhibit efflux-related resistance in Staphylococcus aureus-Reference-Cited by-同舟云学术

Benzocyclohexane oxide derivatives and neolignans from Piper betle inhibit efflux-related resistance in Staphylococcus aureus

Published:2016 Issue:49 Volume:6 Page:43518-43525
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Sun Zhong-Lin¹²³⁴,He Jian-Ming¹²³⁴,Wang Shuang-Ying¹²³⁴,Ma Ru¹²³⁴,Khondkar Proma⁵⁶⁷⁸,Kaatz Glenn W.⁹¹⁰¹¹¹²¹³,Gibbons Simon⁵⁶⁷⁸,Mu Qing¹²³⁴

Affiliation:

1. School of Pharmacy

2. Fudan University

3. Shanghai 201203

4. China

5. Research Department of Pharmaceutical and Biological Chemistry

6. UCL School of Pharmacy

7. London WC1N 1AX

8. UK

9. The John D. Dingell Department of Veteran's Affairs Medical Centre and Department of Internal Medicine

10. Division of Infectious Diseases

11. School of Medicine

12. Wayne State University

13. Detroit

Abstract

Six active compounds were isolated fromPiper betleunder the guide of synergistic effects combined with antibiotic norfloxacin. The synergistic mechanism was explored and significant inhibition effects for EtBr efflux in SA1199B were found.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C6RA10199B

Reference34 articles.

1. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

2. Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat

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