Copper-catalyzed asymmetric propargylation of imines enabled by a biphenol-based phosphoramidite ligand-Reference-Cited by-同舟云学术

Copper-catalyzed asymmetric propargylation of imines enabled by a biphenol-based phosphoramidite ligand

Published:2023 Issue:19 Volume:10 Page:4935-4940
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Yan Qi-Qi¹,Ruan Cheng-Kai¹,Deng Yu-Qin¹,Pu Yu-Chuan¹,Chu Wen-Dao¹^ORCID,He Cheng-Yu¹^ORCID,Liu Quan-Zhong¹^ORCID

Affiliation:

1. Chemical Synthesis and Pollution Control Key Laboratory of Sichuan Province, College of Chemistry and Chemical Engineering, China West Normal University, No. 1, Shida Road, Nanchong 637002, China

Abstract

Cu-catalyzed asymmetric propargylation of acyclic imines with electron-neutral protecting groups was established, providing the corresponding homopropargyl amines in excellent yields and high enantioselectivities.

Funder

Natural Science Foundation of Sichuan Province

National Natural Science Foundation of China

Fundamental Research Funds of China West Normal University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/QO/D3QO00871A

Reference28 articles.

1. Biomimetic Total Synthesis of (+)-Gelsemine

2. Stereoselective Synthesis of syn-β-Amino Propargylic Ethers: Application to the Asymmetric Syntheses of (+)-β-Conhydrine and (−)-Balanol

3. Asymmetric Total Synthesis of (+)-6-epi-Castanospermine by the Stereoselective Formation of a syn,anti Acetylenic 2-Amino-1,3-diol Stereotriad

4. A 7-Step Formal Asymmetric Total Synthesis of Strictamine via an Asymmetric Propargylation and Metal-Mediated Cyclization

5. Cu(OAc)2/TEMPO Cooperative Promoted Hydroamination Cyclization and Oxidative Dehydrogenation Cascade Reaction of Homopropargylic Amines

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