Recognizing drug targets using evolutionary information: implications for repurposing FDA-approved drugs against Mycobacterium tuberculosis H37Rv-Reference-Cited by-同舟云学术

Recognizing drug targets using evolutionary information: implications for repurposing FDA-approved drugs against Mycobacterium tuberculosis H37Rv

Published:2015 Issue:12 Volume:11 Page:3316-3331
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Ramakrishnan Gayatri¹²³⁴⁵,Chandra Nagasuma R.⁶²³⁴,Srinivasan Narayanaswamy⁵²³⁴

Affiliation:

1. Indian Institute of Science Mathematics Initiative

2. Indian Institute of Science

3. Bangalore-560012

4. India

5. Molecular Biophysics Unit

6. Department of Biochemistry

Abstract

Drug repurposing to explore target space has been gaining pace over the past decade with the upsurge in the use of systematic approaches for computational drug discovery.

Funder

Department of Biotechnology, Ministry of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MB/C5MB00476D

Reference204 articles.

1. Drug repositioning: identifying and developing new uses for existing drugs

2. The Mycobacterium tuberculosis Drugome and Its Polypharmacological Implications

3. Drug Discovery Using Chemical Systems Biology: Repositioning the Safe Medicine Comtan to Treat Multi-Drug and Extensively Drug Resistant Tuberculosis

4. Drug Target Identification Using Side-Effect Similarity

5. Relating protein pharmacology by ligand chemistry

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