Cu2+ selective chelators relieve copper-induced oxidative stress in vivo

Author:

Rakshit Ananya1234ORCID,Khatua Kaustav1234ORCID,Shanbhag Vinit56789ORCID,Comba Peter1011121314ORCID,Datta Ankona1234ORCID

Affiliation:

1. Department of Chemical Sciences

2. Tata Institute of Fundamental Research

3. Mumbai-400005

4. India

5. Department of Biochemistry

6. Christopher S. Bond Life Science Center

7. University of Missouri

8. Columbia

9. USA

10. Universität Heidelberg

11. Anorganisch-Chemisches Institut

12. Interdisciplinary Center for Scientific Computing

13. D-69120 Heidelberg

14. Germany

Abstract

We report highly selective, novel Cu2+ chelators that relieve copper induced oxidative stress in vivo indicating applicability toward assuaging copper-overload disorders.

Funder

Tata Institute of Fundamental Research

Department of Atomic Energy, Government of India

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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