Synthesis, gene silencing activity, thermal stability, and serum stability of siRNA containing four (S)-5′-C-aminopropyl-2′-O-methylnucleosides (A, adenosine; U, uridine; G, guanosine; and C, cytidine)-Reference-Cited by-同舟云学术

Synthesis, gene silencing activity, thermal stability, and serum stability of siRNA containing four (S)-5′-C-aminopropyl-2′-O-methylnucleosides (A, adenosine; U, uridine; G, guanosine; and C, cytidine)

Published:2022 Issue:18 Volume:12 Page:11454-11476
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kajino Ryohei¹,Sakamoto Shuichi²,Ueno Yoshihito¹³⁴⁵^ORCID

Affiliation:

1. United Graduate School of Agricultural Science, Gifu University, Japan

2. Institute of Microbial Chemistry (BIKAKEN) Numazu Branch, Microbial Chemistry Research Foundation, 18-24 Miyamoto, Numazu, Shizuoka 410-0301, Japan

3. Department of Life Science and Chemistry, The Graduate School of Natural Science and Technology, Gifu University, Japan

4. Course of Applied Life Science, Faculty of Applied Biological Sciences, Gifu University, Japan

5. Center for Highly Advanced Integration of Nano and Life Sciences (G-CHAIN), Gifu University, 1-1 Yanagido, Gifu, 501-1193, Japan

Abstract

(S)-5′-C-Aminopropyl-2′-O-methylnucleosides would be useful for improving the serum stability of therapeutic siRNA molecules without affecting their RNAi activities.

Funder

Japan Agency for Medical Research and Development

Japan Science and Technology Agency

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/RA/D2RA00705C

Reference36 articles.

1. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

2. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

3. RNA interference is mediated by 21- and 22-nucleotide RNAs

4. Overcoming cellular barriers for RNA therapeutics

5. Worth the RISC?

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