Synthesis and biological evaluation of 4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamides and their zinc(ii) complexes as candidate antidiabetic agents-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of 4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamides and their zinc(ii) complexes as candidate antidiabetic agents

Published:2017 Issue:13 Volume:41 Page:5572-5581
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Saito Ryota¹²³⁴⁵^ORCID,Tamura Moe¹²³⁴,Kawano Saya¹²³⁴,Yoshikawa Yutaka⁶⁷⁸⁹⁴,Kato Akihiro¹²³⁴,Sasaki Kaname¹²³⁴,Yasui Hiroyuki¹⁰¹¹¹²⁴

Affiliation:

1. Department of Chemistry

2. Toho University

3. Chiba 274-8510

4. Japan

5. Research Center for Materials with Integrated Properties

6. Department of Health

7. Sports and Nutrition

8. Kobe Women's University

9. Kobe 650-0046

10. Department of Analytical and Bioinorganic Chemistry

11. Kyoto Pharmaceutical University

12. Kyoto 607-8414

Abstract

Five new zinc(ii) complexes with 4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxamides were synthesized, and four of them exhibited insulin-mimetic activity in vitro.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2017/NJ/C7NJ00970D

Reference38 articles.

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2. The Rising Global Burden of Diabetes and its Complications: Estimates and Projections to the Year 2010

3. The role of oral antidiabetic agents: why and when to use an early-phase insulin secretion agent in Type II diabetes mellitus

4. Biochemistry and molecular cell biology of diabetic complications

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