Cisplatin-induced duplex dissociation of complementary and destabilized short GG-containing duplex RNAs-Reference-Cited by-同舟云学术

Cisplatin-induced duplex dissociation of complementary and destabilized short GG-containing duplex RNAs

Published:2014 Issue:31 Volume:43 Page:11941-11949
ISSN:1477-9226
Container-title:Dalton Trans.
language:en
Short-container-title:Dalton Trans.

Author:

Polonyi Christopher¹²³⁴,Alshiekh Alak¹²³⁴,Sarsam Lamya A.¹²³⁴,Clausén Maria¹²³⁴,Elmroth Sofi K. C.¹²³⁴

Affiliation:

1. Biochemistry and Structural Biology

2. KILU

3. Lund University

4. SE-221 00 Lund, Sweden

Abstract

The reactivity of a series of small size RNAs towards mono-aquated cisplatin was monitored using UV/vis spectroscopy. Subtle changes of local melting behavior were found to influence metal binding kinetics, with an increase in reactivity following central destabilization.

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/DT/C4DT00213J

Reference60 articles.

1. Platinum Anticancer Coordination Compounds: Study of DNA Binding Inspires New Drug Design

2. Platinum Compounds: a New Class of Potent Antitumour Agents

3. DNA-Damaging Agents in Cancer Chemotherapy: Serendipity and Chemical Biology

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