Synthesis and characterization of a novel pH-responsive drug-releasing nanocomposite hydrogel for skin cancer therapy and wound healing

Author:

Gonsalves Andrea1,Tambe Pranjali23,Le Duong1,Thakore Dheeraj23,Wadajkar Aniket S.2345,Yang Jian6,Nguyen Kytai T.23,Menon Jyothi U.17ORCID

Affiliation:

1. Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, USA

2. Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA

3. Department of Biomedical Engineering, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA

4. Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA

5. Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA

6. Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA

7. Department of Chemical Engineering, University of Rhode Island, Kingston, RI 02881, USA

Abstract

Inadequate excision of skin cancer can lead to local recurrence. A novel in situ-forming nanocomposite hydrogel with antimicrobial properties is reported for wound healing and localized pH-responsive treatment against skin cancer recurrence.

Funder

National Heart, Lung, and Blood Institute

Rhode Island Foundation

National Institute of Arthritis and Musculoskeletal and Skin Diseases

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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