Defining the molecular structure of teixobactin analogues and understanding their role in antibacterial activities

Author:

Parmar Anish12345,Prior Stephen H.6345,Iyer Abhishek12345,Vincent Charlotte S.78345,Van Lysebetten Dorien910111213,Breukink Eefjan1415161718,Madder Annemieke910111213,Taylor Edward J.78345,Singh Ishwar12345ORCID

Affiliation:

1. School of Pharmacy

2. JBL Building

3. University of Lincoln

4. Lincoln LN6 7DL

5. UK

6. School of Chemistry

7. School of Life Sciences

8. Joseph Bank Laboratories

9. Organic and Biomimetic Chemistry Research Group

10. Department of Organic Chemistry

11. Ghent University

12. B-9000 Ghent

13. Belgium

14. Department of Membrane Biochemistry and Biophysics

15. Institute of Biomembranes

16. Utrecht University

17. 3584 CH Utrecht

18. The Netherlands

Abstract

In this work, we have for the first time defined the molecular structure of seven teixobactin analogues through the variation of the d/l configuration of its key residues.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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