Glucuronyl C4 dehydrogenation by the radical SAM enzyme BlsE involved in blasticidin S biosynthesis-Reference-Cited by-同舟云学术

Glucuronyl C4 dehydrogenation by the radical SAM enzyme BlsE involved in blasticidin S biosynthesis

Published:2022 Issue:21 Volume:58 Page:3561-3564
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Li He¹,Zhao Junfeng²,Ding Wei²,Zhang Qi¹^ORCID

Affiliation:

1. Department of Chemistry, Fudan University, Shanghai, 200433, China

2. State Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China

Abstract

Here we show that, instead of decarboxylation observed previously, the radical S-adenosylmethionine enzyme BlsE catalyzes the C4′-dehydrogenation of cytosylglucuronamide (CGM), and the resulting C4′-ketone compound is modified by the aminotransferase BlsH to install a C4′-amino group.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D1CC07132G

Reference39 articles.

1. Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit

2. Inhibition of DNA synthesis by cycloheximide and blasticidin-s is independent of their effect on protein synthesis

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