Synthesis and preclinical evaluation of a novel, selective 111In-labelled aminoproline-RGD-peptide for non-invasive melanoma tumor imaging-Reference-Cited by-同舟云学术

Synthesis and preclinical evaluation of a novel, selective 111In-labelled aminoproline-RGD-peptide for non-invasive melanoma tumor imaging

Published:2015 Issue:12 Volume:6 Page:2175-2183
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Sartori Andrea¹²³⁴,Bianchini Francesca⁵⁶⁷⁸⁴,Migliari Silvia⁹¹⁰¹¹⁴,Burreddu Paola¹²¹³¹⁴⁴,Curti Claudio¹²³⁴,Vacondio Federica¹²³⁴,Arosio Daniela¹⁵¹³¹⁶⁴,Ruffini Livia⁹¹⁰¹¹⁴,Rassu Gloria¹²¹³¹⁴⁴,Calorini Lido⁵⁶⁷⁸⁴,Pupi Alberto⁵⁶⁷⁸⁴,Zanardi Franca¹²³⁴,Battistini Lucia¹²³⁴

Affiliation:

1. Dipartimento di Farmacia

2. Università degli Studi di Parma

3. Parma 43124

4. Italy

5. Dipartimento di Scienze Biomediche

6. Sperimentali e Cliniche “Mario Serio”

7. Università degli Studi di Firenze

8. Firenze 50134

9. Dipartimento di Medicina Nucleare

10. Azienda Ospedaliero-Universitaria di Parma

11. Parma 43126

12. Istituto di Chimica Biomolecolare

13. Consiglio Nazionale delle Ricerche

14. Sassari 07100

15. Istituto di Scienze e Tecnologie Molecolari

16. Milano 20133

Abstract

An ¹¹¹In-labelled Amp-based RGD-DOTA conjugate was synthesized and evaluated in preclinical models of human melanoma as a novel integrin-targeted SPECT imaging tracer.

Funder

Ente Cassa di Risparmio di Firenze

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/MD/C5MD00301F

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