Mode of action of recombinant hypoxanthine–guanine phosphoribosyltransferase from Mycobacterium tuberculosis
Author:
Affiliation:
1. Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF)
2. Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB)
3. Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
4. Porto Alegre
5. Brazil
Abstract
Homodimeric Mycobacterium tuberculosis HGPRT follows a sequential compulsory ordered enzyme mechanism.
Funder
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/RA/C5RA14918E
Reference45 articles.
1. World Health Organization , Global Tuberculosis Report 2013, WHO Press, Geneva, 2014
2. The resumption of consumption: a review on tuberculosis
3. Extensively drug-resistant tuberculosis: current challenges and threats
4. Totally drug-resistant tuberculosis strains: evidence of adaptation at the cellular level
5. Hypoxia: a window intoMycobacterium tuberculosislatency
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1. Ile209 of Leishmania donovani xanthine phosphoribosyltransferase plays a key role in determining its purine base specificity;FEBS Letters;2021-07-26
2. Hypoxanthine-Guanine Phosphoribosyltransferase Is Dispensable for Mycobacterium smegmatis Viability;Journal of Bacteriology;2020-02-11
3. Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction;eLife;2019-09-25
4. Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction;2019-04-28
5. Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase;European Journal of Medicinal Chemistry;2018-11
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