Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs-Reference-Cited by-同舟云学术

Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs

Published:2009 Issue:9 Volume:11 Page:1823-1827
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Aitipamula Srinivasulu¹²³⁴⁴,Chow Pui Shan¹²³⁴⁴,Tan Reginald B. H.¹²³⁴⁴

Affiliation:

1. Institute of Chemical and Engineering Sciences

2. A*STAR (Agency for Science, Technology and Research)

3. Jurong Island

4. Singapore

Abstract

The first example of a trimorphic cocrystal involving two active pharmaceutical ingredients, ethenzamide and gentisic acid, is reported; metastable polymorphs convert to the stable form upon solid-state grinding; pharmaceutical cocrystals involving two or more APIs have potential relevance to combination drugs.

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2009/CE/B904616J

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