Rational design of a lipid-droplet-polarity based fluorescent probe for potential cancer diagnosis-Reference-Cited by-同舟云学术

Rational design of a lipid-droplet-polarity based fluorescent probe for potential cancer diagnosis

Published:2018 Issue:85 Volume:54 Page:12093-12096
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Yin Junling¹²³⁴⁵,Peng Min¹²³⁴⁵,Ma Yanyan¹²³⁴⁵^ORCID,Guo Rui⁶⁷⁸⁹¹⁰,Lin Weiying¹²³⁴⁵^ORCID

Affiliation:

1. Institute of Fluorescent Probes for Biological Imaging

2. School of Chemistry and Chemical Engineering

3. School of Materials Science and Engineering

4. University of Jinan

5. Jinan

6. State Key Laboratory of Chemo/Biosensing and Chemometrics

7. College of Chemistry and Chemical Engineering

8. Hunan University

9. Changsha

10. P. R. China

Abstract

We have rationally designed a robust fluorescent probe CTPA for potential cancer diagnosis by monitoring LD numbers and polarity variation. With the outstanding solvatochromism and high specificity for LDs of CTPA, the diagnosis of cancer can be achieved not only at the cellular levels but also in organs and living mice for the first time.

Funder

National Natural Science Foundation of China

Taishan Scholar Foundation of Shandong Province

University of Jinan

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CC/C8CC07398H

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3. Prostate-specific antigen: A review of the validation of the most commonly used cancer biomarker

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