Combined photoredox/engineered P450 enzymatic direct dioxygen-functionalization of arylalkanes to chiral acyloins-Reference-Cited by-同舟云学术

Combined photoredox/engineered P450 enzymatic direct dioxygen-functionalization of arylalkanes to chiral acyloins

Published:2022 Issue:46 Volume:20 Page:9085-9092
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Wang Jing¹²³,Wang Hezhen³,Wei Chunyong³,Zhang Lei³^ORCID,Cui Baodong³,Wang Zhongqiang³^ORCID,Zhang Yun³,Wan Nanwei³,Aisa Haji Akber¹²^ORCID,Chen Yongzheng¹²³^ORCID

Affiliation:

1. State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, And CAS Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China

2. University of Chinese Academy of Sciences, Beijing, 100049, China

3. Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Key Laboratory of Basic Pharmacology of Ministry of Education, School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China

Abstract

This study has described an efficient, mild, and highly enantioselective one-pot two-step cascade reaction to access chiral α-hydroxyketones from arylalkanes, combining photoredox/P450 enzymatic direct dioxygen-functionalization of arylalkanes α/β C–H bonds.

Funder

National Natural Science Foundation of China

Guizhou Science and Technology Department

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01769E

Reference99 articles.

1. Photoenzymatic enantioselective intermolecular radical hydroalkylation

2. Photoexcitation of flavoenzymes enables a stereoselective radical cyclization