Stepwise synthesis of 2,6-difunctionalized ethyl pyrazolo[1,5-<i>a</i>]pyrimidine-3-carboxylate <i>via</i> site-selective cross-coupling reactions: experimental and computational studies-Reference-Cited by-同舟云学术

Stepwise synthesis of 2,6-difunctionalized ethyl pyrazolo[1,5-a]pyrimidine-3-carboxylate via site-selective cross-coupling reactions: experimental and computational studies

Published:2022 Issue:48 Volume:20 Page:9684-9697
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Messaoudi Chaima¹²,Jismy Badr¹,Jacquemin Johan³^ORCID,Allouchi Hassan⁴,M'Rabet Hédi²,Abarbri Mohamed¹^ORCID

Affiliation:

1. Laboratoire de Physico-Chimie des Matériaux et des Electrolytes pour l'Energie (PCM2E), EA 6299. Université de Tours, Faculté des Sciences et Techniques, Avenue Monge Faculté des Sciences, Parc de Grandmont, 37200 Tours, France

2. Laboratoire de Synthese Organique Sélective et Hétérocyclique-Evaluation de l'Activité Biologique, Faculté des Sciences de Tunis, Université de Tunis El Manar, Tunis 2092, Tunisia

3. Materials Science and Nano-Engineering (MSN) Department, Mohammed VI Polytechnic University (UM6P), Lot 660−Hay Moulay Rachid, Benguerir 43150, Morocco

4. Faculté de Pharmacie, Université de Tours, EA 7502 SIMBA, 31 Avenue Monge, 37200 Tours, France

Abstract

A variety of novel disubstituted 2-(alknyl, aryl and arylamine)-6-alkynylpyrazolo[1,5-a]pyrimidine derivatives was prepared via sequential site-selective cross-coupling reactions from 2,6-dibromopyrazolo[1,5-a]pyrimidine 3.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB01760A

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