Identification and characterization of stressed degradation products of rabeprazole using LC-ESI/MS/MS and 1H-NMR experiments: in vitro toxicity evaluation of major degradation products-Reference-Cited by-同舟云学术

Identification and characterization of stressed degradation products of rabeprazole using LC-ESI/MS/MS and 1H-NMR experiments: in vitro toxicity evaluation of major degradation products

Published:2016 Issue:13 Volume:6 Page:10719-10735
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Bhandi Murali Mohan¹²³⁴,Borkar Roshan M.¹²³⁴,Shankar G.¹²³⁴,Raut Snehal⁵⁶⁴,Nagesh Narayana⁷⁸⁴,Srinivas R.¹²³⁴

Affiliation:

1. National Centre for Mass Spectrometry

2. CSIR-Indian Institute of Chemical Technology

3. Hyderabad

4. India

5. Hislop School of Biotechnology

6. Nagpur

7. CSIR-Centre for Cellular and Molecular Biology

8. Hyderabad 500007

Abstract

Rabeprazole, an antiulcer drug in the class of proton pump inhibitors was subjected to force degradation studies as per ICH guidelines Q1A (R2).

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/RA/C5RA27965H

Reference30 articles.

1. The role of analytical chemistry in drug-stability studies

2. ICH guideline , Q1A (R2) Stability Testing of New Drug Substances and Products, International Conference on Harmonization, IFPMA, Geneva, Switzerland, 2000

3. Identification and characterization of stressed degradation products of prulifloxacin using LC–ESI-MS/Q-TOF, MSn experiments: Development of a validated specific stability-indicating LC–MS method

4. Identification and characterization of stressed degradation products of metoprolol using LC/Q-TOF-ESI-MS/MS and MSn experiments

5. Liquid chromatography/electrospray ionization tandem mass spectrometric study of milnacipran and its stressed degradation products

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bicyclic 5-6 Systems With One Bridgehead (Ring Junction) Nitrogen Atom: Three Extra Heteroatoms 1:2;Comprehensive Heterocyclic Chemistry IV;2022

2. A Comprehensive Stability Study of Vardenafil Using Quality by Design Approach;Chromatographia;2021-06-19

3. Rabeprazole: A comprehensive profile;Profiles of Drug Substances, Excipients and Related Methodology;2021

4. Stress degradation study of bortezomib: effect of co-solvent, isolation and characterization of degradation products by UHPLC-Q-TOF-MS/MS and NMR and evaluation of the toxicity of the degradation products;New Journal of Chemistry;2021

5. Identification and characterization of degradation products of Remdesivir using liquid chromatography/mass spectrometry;New Journal of Chemistry;2021