High throughput screening of complex biological samples with mass spectrometry – from bulk measurements to single cell analysis-Reference-Cited by-同舟云学术

High throughput screening of complex biological samples with mass spectrometry – from bulk measurements to single cell analysis

Published:2019 Issue:3 Volume:144 Page:872-891
ISSN:0003-2654
Container-title:The Analyst
language:en
Short-container-title:Analyst

Author:

Kempa Emily E.¹²³⁴⁵^ORCID,Hollywood Katherine A.⁶²³⁷⁵^ORCID,Smith Clive A.⁸⁹¹⁰¹¹⁵^ORCID,Barran Perdita E.¹²³⁴⁵^ORCID

Affiliation:

1. Michael Barber Centre for Collaborative Mass Spectrometry

2. Manchester Institute of Biotechnology

3. The University of Manchester

4. Manchester

5. UK

6. Manchester Centre for Synthetic Biology of Fine and Speciality Chemicals (SYNBIOCHEM)

7. Manchester M1 7DN

8. Sphere Fluidics Limited

9. The Jonas-Webb Building

10. Babraham Research Campus

11. Cambridge

Abstract

We review the state of the art in HTS using mass spectrometry with minimal sample preparation from complex biological matrices. We focus on industrial and biotechnological applications.

Funder

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/AN/C8AN01448E

Reference200 articles.

1. High-throughput screening assays for the identification of chemical probes

2. High-throughput screening: new technology for the 21st century

3. High-throughput platforms for metabolomics

4. High-throughput and ultra-high-throughput screening: solution- and cell-based approaches

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