Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking

Author:

Zhang Lin12345,Shen Hao678910,Gong Yiyi111213514,Pang Xiaojing15164514,Yi Meiqi12345,Guo Lin12345,Li Jin12345,Arroyo Sam17181910,Lu Xin17181910,Ovchinnikov Sergey678910,Cheng Gong15164514,Liu Xudong111213514,Jiang Xu111213514,Feng Shan20212214,Deng Haiteng12345ORCID

Affiliation:

1. MOE Key Laboratory of Bioinformatics

2. Center for Synthetic and Systems Biology

3. School of Life Sciences

4. Tsinghua University

5. Beijing

6. Institute for Protein Design

7. Department of Biochemistry

8. University of Washington

9. Seattle

10. USA

11. Central Research Laboratory

12. Peking Union Medical College Hospital

13. Chinese Academy of Medical Sciences and Peking Union Medical College

14. China

15. Tsinghua-Peking Center for Life Sciences

16. School of Medicine

17. Department of Biological Sciences

18. University of Notre Dame

19. South Bend

20. Mass Spectrometry Facility

21. Westlake Lake University

22. Hangzhou

Abstract

Long peptide DCAF enables high selectivity to target harmful antibodies, providing new thoughts for antibody-induced disease intervention.

Funder

Tsinghua University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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