Xanthone-based solvatochromic fluorophores for quantifying micropolarity of protein aggregates-Reference-Cited by-同舟云学术

Xanthone-based solvatochromic fluorophores for quantifying micropolarity of protein aggregates

Published:2022 Issue:42 Volume:13 Page:12540-12549
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Wang Lushun¹^ORCID,Hsiung Chia-Heng²³,Liu Xiaojing²,Wang Shichao¹,Loredo Axel¹^ORCID,Zhang Xin²³^ORCID,Xiao Han¹⁴⁵^ORCID

Affiliation:

1. Department of Chemistry, Rice University, 6100 Main Street, Houston, Texas, 77005, USA

2. Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA

3. Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA

4. Department of Biosciences, Rice University, 6100 Main Street, Houston, Texas, 77005, USA

5. Department of Bioengineering, Rice University, 6100 Main Street, Houston, Texas, 77005, USA

Abstract

Using a single atom substitution approach, we have developed a series of solvatochromic fluorophores that respond solely to polarity. The utility of these fluorophores is demonstrated by quantifying the polarity of misfolded and aggregated proteins.

Funder

Welch Foundation

Pew Charitable Trusts

U.S. Department of Defense

Cancer Prevention and Research Institute of Texas

National Institutes of Health

John S. Dunn Foundation

Burroughs Wellcome Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC05004H

Reference63 articles.

1. Principles that Govern the Folding of Protein Chains

2. Principles of protein folding, misfolding and aggregation

3. Adapting Proteostasis for Disease Intervention

4. What is the role of protein aggregation in neurodegeneration?

5. Chemical Biology Framework to Illuminate Proteostasis

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