High-performance bilayer composites for the replacement of osteochondral defects

Author:

Oliveira A. S.123ORCID,Silva J. C.456,Figueiredo L.7,Ferreira F. C.56,Kotov N. A.89,Colaço R.2,Serro A. P.13ORCID

Affiliation:

1. Centro de Química Estrutural, Institute of Molecular Sciences and Department of Chemical Engineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisbon, Portugal

2. Instituto de Engenharia Mecânica and Department of Mechanical Engineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisbon, Portugal

3. Centro de Investigação Interdisciplinar Egas Moniz, Instituto Universitário Egas Moniz, Quinta da Granja, Monte de Caparica, 2829-511 Caparica, Portugal

4. Centre for Rapid and Sustainable Product Development, Politécnico de Leiria, Rua de Portugal – Zona Industrial, 2430-028 Marinha Grande, Portugal

5. Institute for Bioengineering and Biosciences and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisbon, Portugal

6. Associate Laboratory i4HB – Institute for Health and Bioeconomy, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisbon, Portugal

7. Bioceramed S.A., Rua José Gomes Ferreira 1 Arm. D, 2660-360 São Julião do Tojal, Portugal

8. Biointerfaces Institute and Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA

9. Department of Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA

Abstract

Two novel bilayer constructs for the repair of osteochondral defects were developed from nanofibers and ceramic particles embedded into PVA matrices, exhibiting multiple promising properties similar to those of corresponding natural tissues.

Funder

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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