Enzyme-active liquid coacervate microdroplets as artificial membraneless organelles for intracellular ROS scavenging-Reference-Cited by-同舟云学术

Enzyme-active liquid coacervate microdroplets as artificial membraneless organelles for intracellular ROS scavenging

Published:2022 Issue:16 Volume:10 Page:4588-4595
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Chen Yufeng¹²,Yuan Min¹³,Zhang Yanwen¹,Zhou Shaohong¹,Wang Kemin¹^ORCID,Wu Zhenjun³,Liu Jianbo¹^ORCID

Affiliation:

1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, P. R. China

2. China Tobacco Guangxi Industrial Co., LTD, Nanning 530001, China

3. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China

Abstract

Catalase-containing coacervate microdroplets, developed as artificial membraneless organelles with unique liquid compartments, were integrated into living cells to scavenge intracellular massive reactive oxygen species and recover cell viability.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Hunan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2022/BM/D2BM00713D

Reference36 articles.

1. Active coacervate droplets as a model for membraneless organelles and protocells

2. Template-directed RNA polymerization and enhanced ribozyme catalysis inside membraneless compartments formed by coacervates

3. Spatiotemporal control of coacervate formation within liposomes

4. Intracellular Microreactors as Artificial Organelles to Conduct Multiple Enzymatic Reactions Simultaneously

5. A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

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