Potential roles of hyaluronic acid inin vivoCAR T cell reprogramming for cancer immunotherapy

Author:

Laomeephol Chavee1ORCID,Areecheewakul Sudartip2,Tawinwung Supannikar23,Suppipat Koramit34,Chunhacha Preedakorn5,Neves Nuno M.67ORCID,Luckanagul Jittima Amie18ORCID

Affiliation:

1. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand

2. Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand

3. Chulalongkorn University Cancer Immunology Excellence Center, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

4. Chulalongkorn University Stem Cell and Cell Therapy Research Center, Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand

5. Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand

6. 3B's Research Group, I3Bs – Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark – Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017 Barco, Guimarães, Portugal

7. ICVS/3B's – PT Government Associate Laboratory, Braga, Guimarães, Portugal

8. Center of Excellence in Plant-produced Pharmaceuticals, Chulalongkorn University, Bangkok 10330, Thailand

Abstract

Hyaluronic acid-based nanoparticles can be promising tools for gene delivery in in vivo reprogramming CAR T cells, as well-designed carriers are needed for targeting and transducing circulating T cells.

Funder

Asahi Glass Foundation

Chulalongkorn University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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