Hydroxybenzylidene-indolinones, c-di-AMP synthase inhibitors, have antibacterial and anti-biofilm activities and also re-sensitize resistant bacteria to methicillin and vancomycin-Reference-Cited by-同舟云学术

Hydroxybenzylidene-indolinones, c-di-AMP synthase inhibitors, have antibacterial and anti-biofilm activities and also re-sensitize resistant bacteria to methicillin and vancomycin

Published:2017 Issue:14 Volume:7 Page:8288-8294
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Opoku-Temeng Clement¹²³⁴⁵,Dayal Neetu¹²³⁴⁶,Miller Jacob⁶²³⁴,Sintim Herman O.¹²³⁴⁶^ORCID

Affiliation:

1. Purdue Institute for Drug Discovery

2. Purdue University

3. West Lafayette

4. USA

5. Biochemistry Graduate Program

6. Department of Chemistry

Abstract

Hydroxybenzylidene-indolinones, newly identified inhibitors of c-di-AMP synthases, inhibit biofilm formation, Gram-positive bacterial growth and sensitize resistant bacteria to methicillin and vancomycin.

Funder

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/RA/C6RA28443D

Reference40 articles.

1. Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050?

2. Solving the Antibiotic Crisis

3. Structural Biochemistry of a Bacterial Checkpoint Protein Reveals Diadenylate Cyclase Activity Regulated by DNA Recombination Intermediates