Controllable membrane remodeling by a modified fragment of the apoptotic protein Bax-Reference-Cited by-同舟云学术

Controllable membrane remodeling by a modified fragment of the apoptotic protein Bax

Published:2021 Issue: Volume:232 Page:114-130
ISSN:1359-6640
Container-title:Faraday Discussions
language:en
Short-container-title:Faraday Discuss.

Author:

Schaefer Katherine G.¹,Grau Brayan²³,Moore Nicolas²,Mingarro Ismael³^ORCID,King Gavin M.¹⁴^ORCID,Barrera Francisco N.²^ORCID

Affiliation:

1. Department of Physics and Astronomy, University of Missouri, Columbia, MO 65211, USA

2. Department of Biochemistry & Cellular and Molecular Biology, University of Tennessee, Knoxville, 37996, USA

3. Departament de Bioquímica i Biologia Molecular, Estructura de Recerca Interdisciplinar en Biotecnologia i Biomedicina (ERI BioTecMed), Universitat de València, E-46100 Burjassot, Spain

4. Department of Biochemistry, University of Missouri, Columbia, Missouri, 65211, USA

Abstract

We strategically introduced glutamic acid residues into a short sequence of the Bax protein that constitutively creates membrane pores. The resulting BaxE5 achieves acidity-triggered membrane remodeling.

Funder

National Institute of General Medical Sciences

Generalitat Valenciana

Universitat de València

National Science Foundation

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/FD/D0FD00070A

Reference53 articles.