An efficient lactamisation/N-acyliminium Pictet–Spengler domino strategy for the diasteroselective synthesis of polyhydroxylated quinoxalinone, β-carboline and quinazolinone derivatives

Abstract

A novel Pictet–Spengler cascade sequence has been developed. It involves a lactamisation/N-acyliminium key step and gives a diverse set of sugar-derived fused polycyclic heterocycles diastereoselectively and efficiently.