Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts

Author:

Yan Pu-Cha12,Xie Jian-Hua34565,Zhang Xiang-Dong12,Chen Kang12,Li Yuan-Qiang12,Zhou Qi-Lin34565,Che Da-Qing1265

Affiliation:

1. Zhejiang Jiuzhou Pharmaceutical Co., Ltd.

2. Taizhou City, P. R. China

3. State Key Laboratory and Institute of Elemento-organic Chemistry

4. Nankai University

5. Tianjin 300071, P. R. China

6. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

Abstract

The Ir/SpiroPAP catalyzed direct asymmetric hydrogenation of α-keto acids under mild reaction conditions has been developed.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference71 articles.

1. G. M. Coppola and H. F.Schuster , α-Hydroxy Acids in Enantioselective Synthesis , VCH, Weinheim , Germany , 1997

2. Comprehensive Asymmetric Catalysis , ed. E. N. Jacobsen , A. Pfaltz and H. Yamamoto , Springer , Berlin, Germany , 1999 , vol. I–III

3. Catalysis Asymmetric Synthesis , ed. I. Ojima , Wiley-VCH , New York , 2nd edn, 2000

4. Design of Resolving Agents Based on Crystal Engineering

5. Selective reductions. 37. Asymmetric reduction of prochiral ketones with B-(3-pinanyl)-9-borabicyclo[3.3.1]nonane

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