A decellularized spinal cord extracellular matrix-gel/GelMA hydrogel three-dimensional composite scaffold promotes recovery from spinal cord injury <i>via</i> synergism with human menstrual blood-derived stem cells-Reference-Cited by-同舟云学术

A decellularized spinal cord extracellular matrix-gel/GelMA hydrogel three-dimensional composite scaffold promotes recovery from spinal cord injury via synergism with human menstrual blood-derived stem cells

Published:2022 Issue:30 Volume:10 Page:5753-5764
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

He Wenhua¹,Zhang Xuanxuan¹,Li Xiangzhe²,Ju Dingyue¹,Mao Tiantian¹,Lu Yan¹,Gu Yu¹,Qi Longju³,Wang Qinghua¹⁴,Wu Qinfeng²,Dong Chuanming¹⁴^ORCID

Affiliation:

1. Department of Anatomy, Comparative Medicine Institution, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China

2. Department of Rehabilitation Medicine, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou Science & Technology Town Hospital, Suzhou, 215153, Jiangsu Province, China

3. Department of Hepatic Intervention, Affiliated Nantong Hospital 3 of Nantong University, Nantong 226001, Jiangsu Province, China

4. Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong 226001, Jiangsu Province, China

Abstract

The DSCG, GelMA, and MenSCs were cross-linked by photoinitiators under UV irradiation to make composite scaffolds. The MenSC-encapsulated composite scaffolds were then transplanted into a rat model with complete spinal cord transection.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2022/TB/D2TB00792D

Reference47 articles.

1. Spinal cord repair: advances in biology and technology

2. Cell biology of spinal cord injury and repair