A divergent approach to the synthesis of iGb3 sugar and lipid analogues via a lactosyl 2-azido-sphingosine intermediate
Author:
Affiliation:
1. School of Chemical and Physical Sciences
2. Victoria University of Wellington
3. Wellington, New Zealand
4. Malaghan Institute of Medical Research
Abstract
Isoglobotrihexosylceramide (iGb3, 1) is an immunomodulatory glycolipid that binds to CD1d and is presented to the T-cell receptor (TCR) of invariant natural killer T (iNKT) cells.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB00241E
Reference55 articles.
1. Lysosomal Glycosphingolipid Recognition by NKT Cells
2. Crystal Structures of Mouse CD1d-iGb3 Complex and its Cognate Vα14 T Cell Receptor Suggest a Model for Dual Recognition of Foreign and Self Glycolipids
3. Recognition of β-linked self glycolipids mediated by natural killer T cell antigen receptors
4. Antigen recognition by CD1d-restricted NKT T cell receptors
5. CD1d protein structure determines species-selective antigenicity of isoglobotrihexosylceramide (iGb3) to invariant NKT cells
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