A divergent approach to the synthesis of iGb3 sugar and lipid analogues via a lactosyl 2-azido-sphingosine intermediate

Author:

Cheng Janice M. H.12343,Dangerfield Emma M.12343,Timmer Mattie S. M.123,Stocker Bridget L.12343

Affiliation:

1. School of Chemical and Physical Sciences

2. Victoria University of Wellington

3. Wellington, New Zealand

4. Malaghan Institute of Medical Research

Abstract

Isoglobotrihexosylceramide (iGb3, 1) is an immunomodulatory glycolipid that binds to CD1d and is presented to the T-cell receptor (TCR) of invariant natural killer T (iNKT) cells.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

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