1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials: synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics evaluation-Reference-Cited by-同舟云学术

1-Aryl-1,2,3,4-tetrahydroisoquinolines as potential antimalarials: synthesis, in vitro antiplasmodial activity and in silico pharmacokinetics evaluation

Published:2014 Issue:44 Volume:4 Page:22856-22865
ISSN:2046-2069
Container-title:RSC Adv.
language:en
Short-container-title:RSC Adv.

Author:

Hanna Joelle Ngo¹²³⁴,Ntie-Kang Fidele¹²³⁴,Kaiser Marcel⁵⁶⁷,Brun Reto⁵⁶⁷,Efange Simon M. N.¹²³⁴

Affiliation:

1. Department of Chemistry

2. Faculty of Science

3. University of Buea

4. Buea, Cameroon

5. Department of Medical Parasitology and Infection Biology Parasite Chemotherapy

6. Swiss Tropical Institute

7. Basel, Switzerland

Abstract

In the present study, twenty-one 1-aryl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline (THIQ) analogues were synthesized by base-catalyzed Pictet–Spengler reaction, and testedin vitroagainstP. falciparumusing the [³H]hypoxanthine incorporation assay.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2014/RA/C3RA46791K

Reference43 articles.

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