Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association
Author:
Affiliation:
1. School of Chemistry and Biochemistry
2. University of Western Australia
3. Crawley
4. Australia
5. Institute for Glycomics
6. Department of Chemistry
7. Virginia Commonwealth University
8. Richmond
9. USA
Abstract
The trinuclear platinum drug BB3464 pre-associates in the minor groove at two different sites on a 14-mer duplex and this dictates the nature of the adducts formed in both 5′-5′ and 3′-3′ directions.
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/DT/C4DT02942A
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