Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)-Reference-Cited by-同舟云学术

Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs)

Published:2022 Issue:78 Volume:58 Page:10933-10936
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Zhang Qisi¹^ORCID,Kounde Cyrille S.¹^ORCID,Mondal Milon¹^ORCID,Greenfield Jake L.¹^ORCID,Baker Jennifer R.²^ORCID,Kotelnikov Sergei³⁴^ORCID,Ignatov Mikhail³⁴,Tinworth Christopher P.⁵^ORCID,Zhang Leran¹^ORCID,Conole Daniel¹^ORCID,De Vita Elena¹^ORCID,Kozakov Dima³⁴^ORCID,McCluskey Adam²^ORCID,Harling John D.⁵^ORCID,Fuchter Matthew J.¹^ORCID,Tate Edward W.¹^ORCID

Affiliation:

1. Department of Chemistry, Imperial College London, London, W12 0BZ, UK

2. Chemistry, School of Environmental & Life Sciences, the University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia

3. Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, NY, 11794, USA

4. Laufer Center for Physical and Quantitative Biology, Stony Brook University, Stony Brook, NY, 11794, USA

5. GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK

Abstract

A new class of arylazopyrazole photoswitchable PROTACs (AP-PROTACs) enables light-triggered degradation of a specific ensemble of protein kinases.

Funder

National Institutes of Health

Leverhulme Trust

Engineering and Physical Sciences Research Council

National Health and Medical Research Council

GlaxoSmithKline

National Science Foundation

Marie Sklodowska-Curie Actions

Cancer Research UK

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/CC/D2CC03092F

Reference29 articles.

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2. Perilous journey: a tour of the ubiquitin–proteasome system

3. Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

4. Antibody–PROTAC Conjugates Enable HER2-Dependent Targeted Protein Degradation of BRD4

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