A polysaccharide derived from Lentinus edodes impairs the immunosuppressive function of myeloid-derived suppressor cells via the p38 pathways

Author:

Du Jun12345,Wang Ruijie12345,Zhang Wensheng67895,Zhang Chao67895,Li Xiao67895,Shi Xiaodong67895,Hu Minghua10115,Ma Fangli10115,Ma ChungWah10115,Wang Xiaohong125,Tao Ning67895ORCID,Qin Zhihai67895

Affiliation:

1. Institute of Biotechnology

2. The Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education

3. Shanxi University

4. Taiyuan 030006

5. China

6. Protein and Peptide Pharmaceutical Laboratory

7. Institute of Biophysics

8. Chinese Academy of Sciences

9. Beijing

10. Infinitus Chinese Herbal Immunity Research Centre

11. Guangzhou

12. Zhejiang Province Cancer Hospital

Abstract

MPSSS may reverse the function of the MSC2 cells through p38 activation and ERK suppression and provide a novel anti-cancer strategy by targeting myeloid immune suppressor cells.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

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