QbD-based fabrication of transferrin-anchored nanocarriers for targeted drug delivery to macrophages and colon cells for mucosal inflammation healing-Reference-Cited by-同舟云学术

QbD-based fabrication of transferrin-anchored nanocarriers for targeted drug delivery to macrophages and colon cells for mucosal inflammation healing

Published:2023 Issue:4 Volume:11 Page:1373-1397
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Zeeshan Mahira¹²^ORCID,Ain Qurat Ul¹,Sunny Ahad¹,Raza Faisal³^ORCID,Mohsin Muhammad⁴,Khan Salman¹,Weigmann Benno²,Ali Hussain¹

Affiliation:

1. Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan

2. Department of Medicine 1, University of Erlangen-Nuremberg, Kussmaul Campus for Medical Research, Erlangen 91052, Germany

3. School of Pharmacy, Shanghai Jiao Tong University, Shanghai, 200240, China

4. Riphah Institute of Pharmaceutical Sciences, Islamabad, Pakistan

Abstract

QbD-designed PLGA/transferrin nanocarriers (P/tfr NCs) specifically deliver the drug to the colon by targeting colon epithelial cells and macrophages via overexpressed surface transferrin receptor (TFR-1) to ameliorate inflammation via oral route.

Funder

Higher Education Commision, Pakistan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2023/BM/D2BM01719A

Reference66 articles.

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4. Glycyrrhizic acid-loaded pH-sensitive poly-(lactic-co-glycolic acid) nanoparticles for the amelioration of inflammatory bowel disease

5. A holistic QBD approach to design galactose conjugated PLGA polymer and nanoparticles to catch macrophages during intestinal inflammation

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