Hill kinetics as a noise filter: the role of transcription factor autoregulation in gene cascades
Author:
Affiliation:
1. Institute of Physical Chemistry
2. Polish Academy of Sciences
3. 01-224 Warsaw
4. Poland
Abstract
Multiple genes under control of a single, self-regulating regulator can exhibit different (binary or graded) responses to the same signal.
Funder
Ministerstwo Nauki i Szkolnictwa Wyzszego
Publisher
Royal Society of Chemistry (RSC)
Subject
Physical and Theoretical Chemistry,General Physics and Astronomy
Link
http://pubs.rsc.org/en/content/articlepdf/2017/CP/C7CP00743D
Reference55 articles.
1. Bimodal gene expression in noncooperative regulatory systems
2. Cell-to-Cell Variability in the Propensity to Transcribe Explains Correlated Fluctuations in Gene Expression
3. In search of noise-induced bimodality
4. Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise
5. Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses
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