Stereoselective synthesis of 1,3-disubstituted dihydroisoquinolines vial-phenylalanine-derived dihydroisoquinoline N-oxides
Author:
Affiliation:
1. School of Science and the Environment
2. Manchester Metropolitan University
3. Manchester
4. UK
Abstract
Addition of Grignard reagents and alkenes to readily available (S)-3-(hydroxymethyl)-3,4-dihydroisoquinoline-2-oxide allow the highly stereoselective synthesis of a range of 1,3-disubstituted tetrahydroisoquinolines.
Funder
Engineering and Physical Sciences Research Council
Royal Society
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB02007H
Reference58 articles.
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2. Chemistry and Biology of the Tetrahydroisoquinoline Antitumor Antibiotics
3. β-Phenylethylamines and the isoquinoline alkaloids
4. Diversity-oriented synthesis of medicinally important 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) derivatives and higher analogs
5. Ecteinascidins. A review of the chemistry, biology and clinical utility of potent tetrahydroisoquinoline antitumor antibiotics
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