Beyond the TPP<sup>+</sup>“gold standard”: a new generation mitochondrial delivery vector based on extended PN frameworks-Reference-Cited by-同舟云学术

Beyond the TPP⁺“gold standard”: a new generation mitochondrial delivery vector based on extended PN frameworks

Published:2023 Issue:15 Volume:14 Page:4126-4133
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Ong How Chee¹,Coimbra João T. S.²^ORCID,Ramos Maria J.²^ORCID,Xing Bengang¹^ORCID,Fernandes Pedro A.²^ORCID,García Felipe³⁴^ORCID

Affiliation:

1. School of Physical and Mathematical Sciences, Division of Chemistry and Biological Chemistry, Nanyang Technological University, 21 Nanyang Link, 637371, Singapore

2. LAQV/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, s/n, 4169-007 Porto, Portugal

3. Departamento de Química Orgánica e Inorgánica, Facultad de Química, Universidad de Oviedo, Avda Julian Claveria 8, 33006, Asturias, Spain

4. School of Chemistry, Monash University, Clayton, Victoria 3800, Australia

Abstract

PN frameworks were explored as mitochondrial delivery vectors. The newly designed phosphazenylphosphonium moiety was demonstrated to be more effective than traditional triphenylphosphonium-based vectors.

Funder

Agency for Science, Technology and Research

Nanyang Technological University

Ministry of Education - Singapore

Fundación para el Fomento en Asturias de la Investigación Científica Aplicada y la Tecnología

Ministerio de Ciencia e Innovación

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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