4,4′-Dimethoxychalcone protects the skin from AAPH-induced senescence and UVB-induced photoaging by activating autophagy-Reference-Cited by-同舟云学术

4,4′-Dimethoxychalcone protects the skin from AAPH-induced senescence and UVB-induced photoaging by activating autophagy

Published:2022 Issue:7 Volume:13 Page:4114-4129
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Gu Yanpei¹^ORCID,Han Jianxin¹,Xue Fan¹,Xiao Hongrui¹,Chen Lihuan¹,Zhao Zhenlei¹²,Zhang Ying¹^ORCID

Affiliation:

1. College of Biosystems Engineering and Food Science, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang Engineering Center for Food Technology and Equipment, Zhejiang University, Hangzhou 310058, China

2. Zhejiang Provincial Key Lab of Geriatrics & Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, China

Abstract

Treatment with 1 mM AAPH for 48 h can successfully induce senescence of HaCaT cells, and 4,4′-dimethoxychalcone can inhibit cellular senescence by modulating the p38 MAPK and JNK signaling to activate autophagy.

Funder

Zhejiang University Student Science and Technology Innovation Activity Plan

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2022/FO/D1FO04130D

Reference50 articles.

1. Ageing, neurodegeneration and brain rejuvenation

2. When the skin is in the center of interest: An aging issue

3. Oxidation events and skin aging