A novel approach for the screening analysis of anticancer compounds from traditional Chinese medicine by a G-quadruplex functionalized magnetic system-Reference-Cited by-同舟云学术

A novel approach for the screening analysis of anticancer compounds from traditional Chinese medicine by a G-quadruplex functionalized magnetic system

Published:2020 Issue:4 Volume:12 Page:528-534
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Zhang Yi¹²³⁴⁵,Wu Jia¹²³⁴⁵,Liu Xiuxiu¹²³⁴⁵,Sun Hongxia⁶⁷⁸⁹¹⁰,Chen Yin¹²³⁴⁵,Fu Chunmei¹²³⁴⁵,Xu Xiaoping¹²³⁴⁵,Yang Shu¹²³⁴⁵^ORCID,Tang Yalin⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry

2. Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology

3. West China School of Pharmacy

4. Sichuan University

5. Chengdu

6. National Laboratory for Molecular Sciences

7. Centre for Molecular Sciences

8. State Key Laboratory for Structural Chemistry of Unstable and Stable Species

9. Institute of Chemistry

10. Chinese Academy of Sciences

Abstract

G-quadruplex (G4) is a four-stranded DNA structure, viewed as an emerging therapeutic target in oncology. G4 coated magnetic screening system provides a feasible, easy-operating approach for anticancer drug discovery.

Funder

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/AY/C9AY02345C

Reference33 articles.

1. Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

2. Quantitative visualization of DNA G-quadruplex structures in human cells

3. Human telomere, oncogenic promoter and 5'-UTR G-quadruplexes: diverse higher order DNA and RNA targets for cancer therapeutics

4. Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution

5. G-quadruplexes in promoters throughout the human genome