Conformationally-locked C-glycosides: tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts

Author:

Navo C. D.1234,Corzana F.1234,Sánchez-Fernández E. M.56784,Busto J. H.1234,Avenoza A.1234,Zurbano M. M.1234,Nanba E.910111213,Higaki K.910111213,Ortiz Mellet C.56784ORCID,García Fernández J. M.1415164,Peregrina J. M.1234

Affiliation:

1. Departamento de Química and Centro de Investigación en Síntesis Química

2. Universidad de La Rioja

3. 26006 Logroño

4. Spain

5. Departamento de Química Orgánica

6. Facultad de Química

7. Universidad de Sevilla

8. 41012 Sevilla

9. Division of Functional Genomics

10. Research Center for Bioscience and Technology

11. Tottori University

12. Yonago 683-8503

13. Japan

14. Instituto de Investigaciones Químicas (IIQ)

15. CSIC – Universidad de Sevilla

16. 41092 Sevilla

Abstract

A series of conformationally locked C-glycosides based on the 3-aminopyrano[3,2-b]pyrrol-2(1H)-one (APP) scaffold has been synthesized.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference74 articles.

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3. Iminosugars: from synthesis to therapeutic applications, ed. P. Compain, O. R.Martin, John Wiley & Sons, Ltd, Chichester, England, 1st edn, 2007

4. Imino sugars and glycosyl hydrolases

5. Natural and Synthetic Iminosugars as Carbohydrate Processing Enzyme Inhibitors for Cancer Therapy

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