Magnetic nanocluster-mediated photothermal effect and macrophage modulation for synergistic photothermal immunotherapy of cancer

Author:

Ren Xiaoqing1ORCID,Yuan Wanqiong234,Ma Jing5,Wang Ping5,Sun Suhui5,Wang Shumin5ORCID,Zhao Rongsheng1,Liang Xiaolong5ORCID

Affiliation:

1. Department of Pharmacy, Peking University Third Hospital, Beijing, 100191, China

2. Department of Orthopedics, Peking University Third Hospital, Beijing, 100191, China

3. Beijing Key Laboratory of Spinal Disease, Beijing, China

4. Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, China

5. Department of Ultrasound, Peking University Third Hospital, Beijing, 100191, China

Abstract

Magnetic nanoclusters (MNCs) promote tumor regression and inhibit cancer metastasis through an intrinsic photothermal effect synergized with induced macrophage repolarization and T cell modulation.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

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