Total synthesis of 1α,25-dihydroxyvitamin D3 analogs modified at the side chain and D-ring-Reference-Cited by-同舟云学术

Total synthesis of 1α,25-dihydroxyvitamin D3 analogs modified at the side chain and D-ring

Published:2018 Issue:24 Volume:16 Page:4563-4569
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

López-Pérez Borja¹²³⁴⁵^ORCID,Maestro Miguel A.⁶⁷⁸⁵^ORCID,Mouriño Antonio¹²³⁴⁵^ORCID

Affiliation:

1. Departamento de Química Orgánica

2. Laboratorio de Investigación Ignacio Ribas

3. Universidad de Santiago de Compostela

4. 15782 Santiago de Compostela

5. Spain

6. Departamento de Química-CICA

7. Universidad de A Coruña

8. 15071 A Coruña

Abstract

A general approach to generate the natural or unnatural steroid configuration at C20 and unsaturation at the D-ring is exemplified with the total synthesis of 1α,25-dihydroxyvitamin D₃ analogs 3 and 4.

Funder

Ministerio de Ciencia e Innovación

Consellería de Cultura, Educación e Ordenación Universitaria, Xunta de Galicia

European Regional Development Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/OB/C8OB01002A

Reference35 articles.

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3. N. Kubodera , K.Sato and Y.Nishii , in Vitamin D , ed. D. Feldman , F. H. Glorieux and J. W. Pike , Academic Press , San Diego , 1997 , p. 1071

4. The future of vitamin D analogs

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