Glutamine-chitosan modified calcium phosphate nanoparticles for efficient siRNA delivery and osteogenic differentiation-Reference-Cited by-同舟云学术

Glutamine-chitosan modified calcium phosphate nanoparticles for efficient siRNA delivery and osteogenic differentiation

Published:2015 Issue:31 Volume:3 Page:6448-6455
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Choi Bogyu¹²³⁴,Cui Zhong-Kai¹²³⁴,Kim Soyon⁵²³⁴,Fan Jiabing¹²³⁴,Wu Benjamin M.¹²³⁴⁵,Lee Min¹²³⁴⁵

Affiliation:

1. Division of Advanced Prosthodontics

2. University of California Los Angeles

3. Los Angeles

4. USA

5. Department of Bioengineering

Abstract

CaP nanoparticles coated with highly cationic, glutamine-conjugated oligochitosan (Gln-OChi) are developed for siRNA delivery to significantly enhance gene transfection and knockdown efficiency with minimal cytotoxicity. This new nanocarrier can potentially be used for gene therapy.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2015/TB/C5TB00843C

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